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Serum cystatin C an...
Serum cystatin C and the risk of Alzheimer disease in elderly men
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- Sundelöf, Johan (author)
- Uppsala universitet,Geriatrik
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- Ärnlöv, Johan (author)
- Högskolan Dalarna,Medicinsk vetenskap
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Ingelsson, E. (author)
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- Sundström, J. (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Basu, Samar (author)
- Uppsala universitet,Klinisk nutrition och metabolism
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- Zethelius, Björn (author)
- Uppsala universitet,Geriatrik
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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Irizarry, M. C. (author)
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- Giedraitis, Vilmantas (author)
- Uppsala universitet,Geriatrik
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- Rönnemaa, Elina (author)
- Uppsala universitet,Geriatrik
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- Degerman-Gunnarsson, Malin (author)
- Uppsala universitet,Geriatrik
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Hyman, B. T. (author)
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- Basun, Hans (author)
- Uppsala universitet,Geriatrik
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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(creator_code:org_t)
- 2008-09-29
- 2008
- English.
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In: Neurology. - : Ovid Technologies (Wolters Kluwer Health). - 0028-3878 .- 1526-632X. ; 71:14, s. 1072-1079
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- BACKGROUND: Multiple lines of research suggest that increased cystatin C activity in the brain protects against the development of Alzheimer disease (AD). METHODS: Serum cystatin C levels were analyzed at two examinations of the Uppsala Longitudinal Study of Adult Men, a longitudinal, community-based study of elderly men (age 70 years, n = 1,153 and age 77 years, n = 761, a subset of the age 70 examination). Cox regressions were used to examine associations between serum cystatin C and incident AD. AD cases were identified by cognitive screening and comprehensive medical chart review in all subjects. RESULTS: On follow-up (median 11.3 years), 82 subjects developed AD. At age 70 years, lower cystatin C was associated with higher risk of AD independently of age, APOE4 genotype, glomerular filtration rate, diabetes, hypertension, stroke, cholesterol, body mass index, smoking, education level, and plasma amyloid-beta protein 40 and 42 levels (hazard ratio [HR] for lowest [<1.12 micromol/L] vs highest [>1.30 micromol/L] tertile = 2.67, 95% CI 1.22-5.83, p < 0.02). The results were similar at age 77 years (43 participants developed AD during follow-up). Furthermore, a 0.1-mumol/L decrease of cystatin C between ages 70 and 77 years was associated with a 29% higher risk of incident AD (HR 1.29, 95% CI 1.03-1.63, p < 0.03). CONCLUSIONS: Low levels of serum cystatin C precede clinically manifest Alzheimer disease (AD) in elderly men free of dementia at baseline and may be a marker of future risk of AD. These findings strengthen the evidence for a role for cystatin C in the development of clinical AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
- Hälsa och välfärd
Publication and Content Type
- ref (subject category)
- art (subject category)
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Neurology
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To the university's database
- By the author/editor
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Sundelöf, Johan
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Ärnlöv, Johan
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Ingelsson, E.
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Sundström, J.
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Basu, Samar
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Zethelius, Björn
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Larsson, Anders
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Irizarry, M. C.
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Giedraitis, Vilm ...
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Rönnemaa, Elina
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Degerman-Gunnars ...
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Hyman, B. T.
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Basun, Hans
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Kilander, Lena
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Lannfelt, Lars
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Neurology
- By the university
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Uppsala University
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Högskolan Dalarna